@nehsmit - welcome back to Rachio. Two things to consider - water pressure when running two zones and different characteristics for the zones (amount of sun, slope, plant type).
If there is enough water pressure to run any two zones, then I'd combine zones that are most similar regarding what will impact Rachio Flex calculations - assuming the plan is to run Flex and not a Fixed schedule.
I'd also place misters and emitters on a separate schedule so the Smart Cycle will work, as Smart Cycle won't run if there are any misters or emitters on a schedule.
If there is not enough water pressure to run rotor zone, I might combine misters or emitters as they would have similar run times. Where as a rotor zone would probably not have as long of a run time as a mister or emitter zone.